ENES
At Challenbio, we engineer precision IVD solutions that transform how clinical laboratories approach immunological assessment. Our integrated platform pairs advanced flow cytometry instrumentation with rigorously validated reagent systems—delivering the automation, sensitivity, and reproducibility that today's high-throughput clinical environments demand. Spanning lymphocyte subset enumeration, granular T cell profiling, and multiplexed cytokine quantification, our diagnostic portfolio equips clinicians with deeper immunological insights while simplifying laboratory workflows. Every product is developed under uncompromising quality standards and full regulatory alignment, ensuring that confidence in your results begins at the point of assay design.
6-Color TBNK
Accurate identification and enumeration of T, B, and Natural Killer (NK) cell populations is fundamental to the clinical evaluation of immune status. The Challenbio 6-Color TBNK Reagent provides a standardized, single-tube multicolor flow cytometric solution for comprehensive lymphocyte subset immunophenotyping. This pre-formulated IVD reagent simultaneously identifies CD3+ T cells, CD3+CD4+ helper T cells, CD3+CD8+ cytotoxic T cells, CD3−CD19+ B cells, and CD3−CD16+CD56+ NK cells, while utilizing CD45 for reliable lymphocyte gating. The optimized fluorochrome panel delivers clear population resolution and reproducible results across instruments and operators. Designed for clinical efficiency, the ready-to-use format eliminates manual antibody cocktailing, minimizes pipetting errors, and reduces hands-on time—enabling high-throughput immunological assessment for applications including HIV monitoring, primary immunodeficiency screening, and post-transplant immune surveillance.

Feature

Benefit

Pre-formulated 6-color panel

Eliminates manual cocktailing and reducespreparation errors

Single-tube workflow

Maximizes efficiency and conserves samplevolume

CD45 lymphocyte gating

Ensures accurate population identification

Lot-to-lot consistency

Delivers reproducible results across testingcycles
Multiplex Cytokine
Cytokines are essential soluble mediators that orchestrate the immune response, and their quantitative measurement is critical for evaluating inflammatory status, immune activation, and cytokine storm syndromes. The Challenbio Multiplex Cytokine Detection IVD Reagent leverages bead-based flow cytometric technology to simultaneously quantify multiple key cytokines—including IL-2, IL-4, IL-6, IL-10, TNF-α, and IFN-γ—from a single small-volume biological specimen. This multiplexed approach offers significant advantages over traditional single-analyte ELISA methods, delivering high sensitivity, a broad dynamic range, and substantially reduced sample consumption. The streamlined assay workflow—from sample preparation through automated data acquisition and analysis—enables clinical laboratories to generate comprehensive cytokine profiles efficiently. By providing rapid, quantitative assessment of the cytokine milieu, this solution supports clinicians in the diagnosis and monitoring of sepsis, cytokine release syndrome, autoimmune disorders, and other conditions characterized by immune dysregulation.

Feature

Benefit

Multiplex bead-based detection

Quantifies multiple cytokines simultaneouslyfrom one

sample

Minimal sample volume required

Ideal for pediatric and volume-limited specimens

High sensitivity and broad dynamic range

Detects both low and elevated cytokine levelsaccurately

Streamlined workflow with automated analysis

Reduces turnaround time and improves labefficiency
T Cell Deep Subset
T cell-mediated immunity is the central component of the adaptive immune response, and detailed characterization of T cell differentiation stages provides critical insights for clinical decision-making. The Challenbio T Cell Fine Subset IVD Reagent is an advanced multicolor flow cytometric panel designed to dissect the complex landscape of T cell maturation and activation. This comprehensive assay identifies naïve, central memory, effector memory, and terminally differentiated effector T cell populations within both CD4+ and CD8+ compartments, utilizing well-established markers of differentiation and functional status. The unitized, ready-to-use assay format ensures workflow efficiency and eliminates error-prone antibody titration steps, while the pre-optimized panel design guarantees robust population resolution and assay reproducibility. This solution supports clinicians in evaluating immune reconstitution following stem cell transplantation, monitoring immunotherapy responses, and assessing immune dysregulation in autoimmune and infectious diseases.

Feature

Benefit

Comprehensive T cell differentiation panel

Identifies naive, memory, effector, and terminalsubsets

CD4+ and CD8+ compartment analysis

Provides complete helper and cytotoxic T cellprofiling

Unitized dry or liquid reagent format

Simplifies workflow and ensures consistency

Clinically validated markers

Supports evidence-based immune monitoring